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MEET THE TEAM

Aaron Alexander-Bloch

Aaron Alexander-Bloch

MD, PHD, MPHIL

Hello and welcome to the Brain-Gene Development Lab! I’m Aaron and as the director of the BGD Lab, I work with an incredible group of students, trainees, and scientists. Our shared goal is to understand variability among people in human brain development and to characterize the altered neurogenomic pathways that lead to mental illness. Prior to starting the lab, I trained in philosophy, computational biology, brain MRI, genetics, and clinical psychiatry. I love West Philadelphia, where I live with my family including two young children.
Dabriel Zimmerman

Dabriel Zimmerman

Data Analyst

Hi I’m Dabriel and I joined the lab in 2023 as a clinical research coordinator/data analyst. I’m originally from South Carolina and graduated from the University of South Carolina in 2021. At USC I conducted research utilizing diffusion tensor imaging and tractography to study brain changes across the lifespan in the Richards Infant Lab. Before joining the BGD Lab I spent 2 years as a research coordinator in the Lewis Lab at MIT coordinating multimodal neuroimaging studies focused on sleep and cerebrospinal fluid flow. I will be working on expanding the lab’s current database of clinical and research imaging for our lifespan brain connectome project. Outside of the lab I like to read and am looking forward to exploring Philadelphia!
Lena Dorfschmidt

Lena Dorfschmidt

PHD

Hi! My name is Lena and I am a postdoctoral researcher in the BGD lab. My path here started with a B.Sc. in Cognitive Science at Universität Osnabrück, followed by a PhD as a Gates Cambridge scholar at the University of Cambridge where I focused on understanding structural and functional brain development during adolescence and how it relates to the development of psychiatric disorders. At Penn/CHOP I am working on mapping lifespan brain development, as well as improving our methods for harmonizing large-scale aggregated neuroimaging datasets. Outside the lab you can find me rock climbing, hiking, surfing, enjoying music gigs and veggie food.
Laura Mercedes

Laura Mercedes

Clinical Research Coordinator

Hi! My name is Laura, and I joined the lab in 2024 as a clinical research coordinator. I’m originally from Connecticut and moved to Pennsylvania to complete a bachelor’s degree in both Anthropology and Political Science from Haverford College. I’ve previously conducted ethnographic research concerning the lived experiences of alternative healing practitioners. Within the lab, I will be taking the lead on recruiting participants who have had normal brain MRIs to compose a clinical control group. In my free time I enjoy reading fiction and cooking.
Leila Abdel-Qader

Leila Abdel-Qader

Undergraduate Research Assistant

Hi! I'm Leila Abdel-Qader, one of the undergraduate research interns for the BGD lab. I'm a junior at the University of Pennsylvania on the Pre-Med track, pursuing a Bachelor of Arts in Neuroscience with a minor in Healthcare Management. My research interests follow along the tracks of neuroscience, molecular biology, and genetics. Within the BGD lab, I grade radiology reports to validate the use of clinically acquired MRIs for neurodevelopmental benchmarks, as well as help organize the LBCC dataset for further clinical application. Outside of lab and schoolwork, I enjoy playing tennis, playing with my cats, and binge-watching shows.
Kat Cyr

Kat Cyr

MS

I’m a data scientist with a passion for using technology to improve health and well-being. Before joining the BGD Lab, I worked on the Apple Heart and Movement Study, using wearable data to explore cardiac health. I hold an MS in Biostatistics from Harvard University, a BA in Mathematics from Amherst College, and an AA from Quinsigamond Community College. I’m committed to advancing equity in STEM and increasing representation in medical research for women, first-generation scholars, and other underrepresented groups. Outside the lab, you can find me running, salsa dancing, or spoiling my dog, Winnie.
Jakob Seidlitz

Jakob Seidlitz

PHD

Hi! My name is Jakob and I’m currently a research scientist in the BGD Lab. I am originally from the Washington, DC area and I received my BS in Brain and Cognitive Sciences from the University of Rochester. I completed a joint PhD program as an NIH OxCam Scholar in the Section on Neurogenomics at the NIH and the Department of Psychiatry at the University of Cambridge. In the lab, I am working on a range of projects spanning genetics and transcriptomics to multimodal imaging and clinical phenomics. Outside the lab, I enjoy exploring new spots in DC/Philly with my family, staying active, and wrangling my dogs and cats.
Smirthi Prem

Smirthi Prem

MD, PHD

Hi, my name is Smrithi, and I am a research track resident in the Department of Psychiatry at Penn Medicine. I received my B.S. in Behavioral Neuroscience at Lehigh University and then completed my MD and PhD at Rutgers Robert Wood Johnson. For my PhD dissertation work, I studied the developmental, cellular, and molecular changes in developing neural cells derived from individuals with both genetic and idiopathic autism. This work piqued my desire to understand how cellular and genetic mechanisms contribute to alteration in brain structures over the course of brain development. Ultimately, my goal is to meld my molecular and cellular background with imaging and data science to develop a multimodal understanding of brain development and neuropsychiatric disorders. To this end, my project in the lab currently focuses on studying genetic disorders that alter brain size. Outside of the lab and the clinic, I love cooking and trying new restaurants, reading absurd young adult novels, and playing board games.
Matt Buczek

Matt Buczek

MSEd

Hi! My name is Matt Buczek, and I am the BGD lab's Clinical Research Program Manager. I completed my Bachelor’s at Haverford College, where I majored in Psychology with a concentration in Neuroscience. I have held clinical research positions at CHOP and Penn, and while at Penn I completed an MSEd in Statistics, Measurement, Assessment, and Research Technology. In my role, I'll provide strategic oversight and support for optimal lab functioning. Outside of work, I enjoy playing racket sports, trying Philly’s best restaurants and coffee shops, and volunteering with the Philadelphia Chapter of Minds Matter.
Shivaram Karandikar

Shivaram Karandikar

Data Analyst

Hello, my name is Shivaram. I joined the BGD Lab in January 2024 as a research intern and now work as a data analyst. I completed my undergraduate studies at the University of Connecticut, where I received a dual degree in Statistics and Linguistics. In the lab, I primarily work on processing and analyzing neuroimaging data. In my free time, I enjoy watching open-wheel racing, reading, and running on rail trails.
Madison Dengel

Madison Dengel

Undergraduate Research Assistant

Hi! My name is Madison, and I joined the lab in August 2024 as an undergraduate research assistant. I am a student at the University of Pennsylvania majoring in Cognitive Science and Psychology. In the lab, I primarily work on grading and annotating neuroimaging data. In my free time, I enjoy hiking, reading, and listening to podcasts.
Habib Akouri

Habib Akouri

Medical Student Research Assistant

Hi! I'm Habib, and I am a medical student at the Perelman School of Medicine at Penn. I grew up near Cleveland, Ohio, and attended The Ohio State University for my B.S. in Neuroscience and a minor in global public health. At Ohio State, I worked with rodent models to study how early life adversity and maternal inflammation affect neurodevelopment. In the lab, I am working to develop brain charts for neurological diagnoses and explore psychopathologies within those phenotypes. Outside of lab, I enjoy playing/watching soccer, reading, and going to the gym.
Ayan Mandal

Ayan Mandal

PHD

Hello! My name is Ayan (pronounced OY-in) and I’m currently a medical student at UPenn. I’m from Long Island, New York, and I went to college at Georgetown University where I majored in Neurobiology and Physics. Prior to medical school, I did a PhD at the University of Cambridge on applying network neuroscience for pre-surgical planning of brain tumor resection. In the lab, I am working on developing brain charts for neuroimaging phenotypes of clinical interest. Outside of the lab, I enjoy writing, lifting heavy(ish) weights, trying new recipes, and curating fun playlists on Spotify.
Zhiqiang Sha

Zhiqiang Sha

PHD

My name is Zhiqiang Sha, and I am currently a postdoctoral researcher at CHOP/UPenn. I completed my Bachelor's and Master's degrees in Molecular Biology at Peking Union Medical College. Subsequently, I earned my Ph.D. in Cognitive Neuroscience from Beijing Normal University. In my current role, my research primarily investigates how genetic, psychosocial, and biological factors contribute to function functional and structural variations in the human brain, and its associations with cognitive deficits in neurodevelopmental disorders. Outside the lab, I enjoy reading books, listening to music and watching movies. These activities provide me with a valuable balance to my work in the lab.
Remo Williams

Remo Williams

MS

Howdy everybody.  I'm Remo, and I am very excited to be joining all of you at the Brain-Gene Development Lab. In 2015, I joined what would evolve into the Translational Research Informatics Group within CHOP's Research Institute and its Department of Biomedical and Health Informatics, where we developed Locutus as a framework to support DICOM de-identification workflows to empower research such as that at the BGD Lab with redacted radiology imaging.  I am feeling incredibly grateful for a full circle welcoming into Dr. Aaron Alexander-Bloch's wonderful team at the BGD Lab, where I look forward to many impactful journeys with our collaborators throughout CHOP, UPenn, LiBI, Cambridge, and beyond. When I'm not clicking on my keyboard, sculpting sounds, or casting bronze, I love enjoying life with my wife and partner of three decades, snowboarding down mountains with our son, and carving around skateparks with my friends of the Love City Surf Club.
Benjamin Jung

Benjamin Jung

PHD

Hi! My name is Ben and I'm currently a T32 postdoctoral researcher at CHOP/UPenn. I'm originally from New Jersey, and I received my bachelor's degree in Biology from McGill University. I completed a joint PhD program through the NIH - Brown University Graduate Partnership program in Neuroscience, where I studied the role of rare variants in ADHD. In the lab, my research primarily explores rare copy number variants, and their relationship to brain structure and psychopathology. Outside of the lab, I enjoy hiking and road trips, especially to visit National Parks!
Sepp Kohler

Sepp Kohler

Undergraduate Research Assistant

Hi! My name is Sepp: Philly native and sophomore at UPenn. On the Pre-Med track, I am majoring in Health & Societies with a concentration in Race and Gender. My work for the lab includes validating clinically obtained MRIs/radiology reports and assisting in team members' projects: where I take great passion in integrating socio-demographics and historical data into our research. Outside of academia, I enjoy gardening, fish-husbandry, beekeeping, and writing poetry.
Kevin Sun

Kevin Sun

MD/PhD Student

Hi, my name is Kevin and I’m a Neuroscience MD/PhD student in the BGD Lab and the Lifespan Informatics and Neuroimaging Center at Penn (PennLINC). I grew up near Cleveland, Ohio, and came to Penn for my B.A. in Biology. My research path has been varied, including work in structural biology, neurodegenerative disease, and sickle cell genetics. However, I’ve always been interested in brain and behavior, and was thrilled to have the opportunity to begin working with PennLINC and the BGD Lab in the fall of 2022 as a part of my MD/PhD at Penn. Since then, I’ve joined the lab as a thesis student, working with functional neuroimaging data to ask questions about development, genetics, and transdiagnostic psychopathology. Outside of research, I enjoy watching movies, weightlifting, and speculative fiction.
Margaret Gardner

Margaret Gardner

PhD Student

Hello there! My name is Margaret and I’m a PhD student in Penn’s Neuroscience Graduate Group. I grew up in Massachusetts and went to Northeastern University for my undergraduate degree in Psychology. Since joining the BGD Lab, I’ve been working on modeling how biological sex and puberty impact the brain’s structure over the lifespan and whether measuring these effects can help us better understand diseases like schizophrenia. When not doing research, I can be found knitting, writing for the student blog, or doting on my dog, Sasquatch.
Eren Kafadar

Eren Kafadar

MD/PhD Student

Hello! My name is Eren, and I'm an MD-PhD student in the Neuroscience graduate group. I grew up in Istanbul, Turkey and went to Yale University for my B.S. in Neuroscience. For my bachelor's thesis I focused on perceptual processing and hallucinations. Since then my specific research path has changed, but my primary interest remains in looking at emergence of psychopathology through a developmental perspective. I officially joined the BGD lab in Spring of 2024, and currently I'm pursuing my thesis project investigating how gestational age at birth is associated with changes in the trajectory of brain development. I hope this project will increase our understanding of how early life factors such as premature birth relates to brain development and risk for neuropsychiatric disorders during childhood. Outside of research, I enjoy cooking, swimming, catching up on movies and tv shows, and listening to podcasts whenever I can.
Briana Macedo

Briana Macedo

MD/PhD Student

Hi! My name is Briana Macedo and I am a Genomics + Computational Biology MD/PhD student. I am originally from New Jersey and completed my Bachelor of Science and Engineering in Computer Science at Princeton University. As an undergraduate, I worked with Dr. Olga Troyanskaya at the Simons Foundation and Lewis-Sigler Institute of Integrative Genomics to create a framework for analyzing the regulatory impact of noncoding genetic mutations. As an aspiring physician-scientist, my goal in the lab is to combine data from brain imaging, genetic sequencing, and clinical data within the EHR to better understand brain development and disease.
Jonathan Berken

Jonathan Berken

MD, PhD

I am a physician-scientist focused on the gut-brain axis in the earliest stages of life. As a combined fellow in Neonatal-Perinatal Medicine and Gastroenterology, Hepatology, and Nutrition at CHOP, my research investigates how gastrointestinal health, including the microbiome, influences brain development and behavior, particularly during critical periods of neuroplasticity. I earned a BA in French and Psychology at Yale, where I studied the impact of language acquisition on the brain. I then pursued a PhD in Cognitive Neuroscience at McGill's Montreal Neurological Institute, using neuroimaging to explore how bilingual exposure affects brain organization. After obtaining my medical degree at the University of Pittsburgh, I completed a Pediatrics residency at the Ann and Robert H. Lurie Children’s Hospital of Chicago and a postdoctoral fellowship at Northwestern's Institute for Innovations in Developmental Science. I live in the Rittenhouse neighborhood of Center City, where I enjoy exploring the city's coffee shops and restaurants, spending time with family and friends, and keeping up with politics and popular culture.

Lab Alumni

Jenna Young
Data Scientist Memorial Sloan Kettering
Shreya Gudapati
Data Analyst
Alfredo Ortiz-Rosa
Industry Data Analyst
Harshini Raman
University of Pittsburgh, Physician Scientist Training Program
Harry Hearn
Former Undergraduate Research Assistant
Nadia Ngom
Former Undergraduate Research Assistant
Caleb Schmitt
Cornell University Undergraduate Student
Nicholas Huffnagle
Casey Chertavian
University College London, PhD Candidate

This statement on Justice, Equity, Diversity and Inclusion is shared by consensus from BGD lab members:

We are guided by a core set of values that we promote within CHOP and Penn, in our work with study participants and their data, and in the dissemination of our results. Our lab is open to people of every race, ethnicity, religion, income, gender, and sexual orientation. We promote dignity for all persons regardless of their physical and mental health status or cognitive abilities. We view community participants as partners to improve our understanding of and treatments for mental illness. We aim to remove historical and contemporary barriers to opportunity for diverse scientists at all levels of training. We will provide training and leadership opportunities for a diverse group of scientists and clinicians across levels of training and professional development.

We recognize longstanding inequities in academia, medicine, and health outcomes. Traumatic life experiences are more common, and access to mental health services is lower, in racially minoritized groups in the United States. We need to do more as a society, and it often feels like our ability to make impactful change is limited. But as scientists and clinicians, we can reach out to our local representatives and give them data to support policy changes; in disseminating our research, we can avoid contributing to misperceptions or negative stereotypes; we can challenge our universities and hospital systems to prioritize Justice, Equity, Diversity and Inclusion as part of their core missions.

CHOP-Penn Lifespan Brain Institute

Richards Biomedical Research Building

3700 Hamilton Walk

Philadelphia, PA 19104

© 2023 Brain-Gene Development Lab

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