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Normative trajectories of extra-axial cerebrospinal fluid during childhood and adolescence defined in a clinically-acquired MRI dataset

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Medrxiv, 2024

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Mandal et al.

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Benign enlargement of the subarachnoid space (BESS), a condition marked by increased extra-axial cerebrospinal fluid (eaCSF) thickness, has been associated with macrocephaly and may be associated with subdural collections. However, diagnosis of BESS is complicated by the lack of age-specific normative data which hinders rigorous investigation of its clinical associations. rowth charts of eaCSF could shed light on normal CSF dynamics while also providing a normative benchmark to assist the diagnosis of BESS and other associated conditions. Our findings indicate that eaCSF thickness evolves in a dynamic pattern throughout childhood and adolescence, and that patients with BESS can be differentiated from clinical controls using computational measurements of eaCSF thickness paired with normative modeling.

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