Copy number variant risk scores affect brain and cognition

How do copy number variants (CNVs) combine with common genetic variants and environmental factors to help explain variability in cognition and psychopathology in our community? For 9498 youths in the Philadelphia area, elevated CNV risk scores were associated with lower cognitive ability, higher overall psychopathology, and higher psychosis-spectrum symptoms. Predictive models of clinical outcomes were improved my integrating rare genetic, common genetic, and environmental factors.