Functional brain networks are associated with both behavior and genetic factors. To uncover clinically translatable mechanisms of psychopathology, it is critical to define how the spatial organization of these networks relates to genetic risk during development. The current study sought to determine the relationship between transdiagnostic polygenic risk scores (PRSs), personalized functional brain networks (PFNs), and overall psychopathology (p-factor) during early adolescence. Findings indicate that polygenic risk for transdiagnostic adulthood psychopathology is associated with both p-factor and PFN topography during early adolescence.